Glucosamine supplements that contain chondroitin also cause palpitations in addition to increased blood pressure. Glucosamine, an amino sugar, is thought to promote the formation and repair of cartilage. While many people use this supplement with great success, some do not have excellent results. Not getting enough or consuming high doses of certain vitamins may cause your body to retain water or swell. In effect, the same condition that causes stiff joints also causes water retention. Chondroitin is believed to help the body maintain fluid and flexibility in the joints. Sodium is amongst the key causes of high blood pressure more so in salt sensitive individuals. Osteoarthritis can also cause water on the knee. Early studies were promising, but the large research that has been done shows no real benefit. If you have arthritis, I recommend reading The Arthritis Cure by Jason Theodosakis, MD, … Although there are some treatment methods available, many individuals will be able to … … 09-23-2005, 02:13 PM #3 I am going to subscribe to this thread - cause I have all kinds of water retention problems - can't say for sure when they happened - I do take MSM & Glucosamine - have no idea if it is linked. Upsides. The concern about glucosamine and blood pressure emanates from the fact that glucosamine supplements especially glucosamine sulphate contains sodium chloride which is a salt (sodium). This tissue is called cartilage. Current data suggests that the increase in blood pressure and heart rate is temporary and does not cause any lasting injury or damage. I've found that some teas will get it down rather quickly. There's no evidence that glucosamine is helpful for joint pain. MSM is commonly taken to relieve arthritis and pain. NSAIDs (including meloxicam) are considered first-line options for mild-to-moderate arthritis-type pain because at correct dosages they are effective, do not cause dependence, and are readily available at a low cost. The amount you take, other medications you take and your own personal constitution will affect how MSM works for you. Glucosamine supplements elevate your blood pressure and heart rate, MayoClinic.com notes. Chondroitin is a naturally occurring substance formed of sugar chains. Elevated Glucose: Some side effects of steroids include, elevated blood sugar, weight gain, fluid retention, high blood pressure, osteoporosis, osteonecrosis, , catarac ... Read More 2 doctors agree When I have fluid retention, now, it's not thyroid related. Certainly it could conceivably cause weight gain. Glucosamine sulfate is a natural sugar found in and around the fluid and tissues that cushion your joints. Vitamins most notable for these effects include vitamins A and C, and thiamine. 2. 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